Drug interactions
Azelastine-fluticasone + Butorphanol
Severity: Moderate
Azelastine-fluticasone and Butorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butorphanol is a sedating opioid analgesic, and azelastine can add drowsiness. The combination may increase sedation and impair alertness, with a possible additive effect on breathing.
What this interaction means in plain words
Azelastine-fluticasone and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Butorphanol belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression from opioid and antihistamine effects.
What to do
Monitor for oversedation and respiratory depression. Use the lowest effective butorphanol dose and advise against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Azelastine-fluticasone with Butorphanol?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butorphanol is a sedating opioid analgesic, and azelastine can add drowsiness. The combination may increase sedation and impair alertness, with a possible additive effect on breathing.
How serious is the interaction between Azelastine-fluticasone and Butorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and respiratory depression. Use the lowest effective butorphanol dose and advise against driving.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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