Drug interactions
Azelastine-fluticasone + Chlordiazepoxide
Severity: Moderate
Azelastine-fluticasone and Chlordiazepoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlordiazepoxide is a long-acting benzodiazepine, and azelastine can add to drowsiness. The combination may increase sedation, dizziness and impaired coordination.
What this interaction means in plain words
Azelastine-fluticasone and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Chlordiazepoxide belongs to Central Nervous System.
Why it happens
Additive central nervous system depression from GABA-A enhancement and H1 blockade.
What to do
Monitor for oversedation and counsel against driving until response is known. Consider a non-sedating alternative to azelastine if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Azelastine-fluticasone with Chlordiazepoxide?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlordiazepoxide is a long-acting benzodiazepine, and azelastine can add to drowsiness. The combination may increase sedation, dizziness and impaired coordination.
How serious is the interaction between Azelastine-fluticasone and Chlordiazepoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and counsel against driving until response is known. Consider a non-sedating alternative to azelastine if needed.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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