Drug interactions
Azelastine-fluticasone + Clonidine
Severity: Minor
Azelastine-fluticasone and Clonidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal azelastine can be sedating, and clonidine also causes sedation and drowsiness. Combined use may increase central nervous system depression, though nasal absorption is limited.
What this interaction means in plain words
Azelastine-fluticasone and Clonidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Clonidine belongs to Cardiovascular.
Why it happens
Additive CNS depressant effects of azelastine and clonidine.
What to do
Advise patients about possible drowsiness and caution when driving. Reduce azelastine use or switch if sedation is troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Azelastine-fluticasone with Clonidine?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Clonidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Intranasal azelastine can be sedating, and clonidine also causes sedation and drowsiness. Combined use may increase central nervous system depression, though nasal absorption is limited.
How serious is the interaction between Azelastine-fluticasone and Clonidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients about possible drowsiness and caution when driving. Reduce azelastine use or switch if sedation is troublesome.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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