Drug interactions
Azelastine-fluticasone + Difenoxin
Severity: Moderate
Azelastine-fluticasone and Difenoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid antidiarrheal that can cause drowsiness and, at higher exposure, CNS depression. Azelastine may add to sedation.
What this interaction means in plain words
Azelastine-fluticasone and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Difenoxin belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from opioid activity and H1 antagonism.
What to do
Counsel the patient about drowsiness and avoid driving until the effect is known. Monitor sedation, particularly in children and older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Difenoxin
Frequently asked questions
Can I take Azelastine-fluticasone with Difenoxin?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid antidiarrheal that can cause drowsiness and, at higher exposure, CNS depression. Azelastine may add to sedation.
How serious is the interaction between Azelastine-fluticasone and Difenoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about drowsiness and avoid driving until the effect is known. Monitor sedation, particularly in children and older adults.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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