Drug interactions
Azelastine-fluticasone + Dipipanone
Severity: Moderate
Azelastine-fluticasone and Dipipanone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipipanone is an opioid analgesic that causes sedation and respiratory depression. Azelastine may add to drowsiness and psychomotor impairment.
What this interaction means in plain words
Azelastine-fluticasone and Dipipanone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid agonism and H1 antagonism.
What to do
Counsel on sedation and avoid driving or hazardous activity. Monitor sedation and respiratory rate, particularly when doses change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Dipipanone?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Dipipanone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipipanone is an opioid analgesic that causes sedation and respiratory depression. Azelastine may add to drowsiness and psychomotor impairment.
How serious is the interaction between Azelastine-fluticasone and Dipipanone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and avoid driving or hazardous activity. Monitor sedation and respiratory rate, particularly when doses change.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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