Drug interactions
Azelastine-fluticasone + Droperidol
Severity: Moderate
Azelastine-fluticasone and Droperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol is a sedating butyrophenone neuroleptic, and azelastine can add to drowsiness. Droperidol also prolongs the QT interval, but azelastine has little systemic effect on QT when given intranasally.
What this interaction means in plain words
Azelastine-fluticasone and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from dopamine antagonism and H1 antagonism.
What to do
Monitor sedation and level of consciousness, particularly after parenteral droperidol. Follow standard droperidol QT precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Droperidol?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droperidol is a sedating butyrophenone neuroleptic, and azelastine can add to drowsiness. Droperidol also prolongs the QT interval, but azelastine has little systemic effect on QT when given intranasally.
How serious is the interaction between Azelastine-fluticasone and Droperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and level of consciousness, particularly after parenteral droperidol. Follow standard droperidol QT precautions.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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