Drug interactions
Azelastine-fluticasone + Ethanol
Severity: Moderate
Azelastine-fluticasone and Ethanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alcohol depresses the CNS, and azelastine labeling warns against concurrent alcohol because of increased drowsiness. Combined use can worsen alertness and coordination.
What this interaction means in plain words
Azelastine-fluticasone and Ethanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from alcohol and H1-receptor antagonism.
What to do
Advise patients to avoid alcohol while using the azelastine-containing spray. Warn against driving or operating machinery if sedated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Ethanol?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Ethanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alcohol depresses the CNS, and azelastine labeling warns against concurrent alcohol because of increased drowsiness. Combined use can worsen alertness and coordination.
How serious is the interaction between Azelastine-fluticasone and Ethanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid alcohol while using the azelastine-containing spray. Warn against driving or operating machinery if sedated.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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