Drug interactions
Azelastine-fluticasone + Loxapine inhaled
Severity: Minor
Azelastine-fluticasone and Loxapine inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine causes sedation and can cause bronchospasm, and it is given under supervision. Azelastine may add to the drowsiness.
What this interaction means in plain words
Azelastine-fluticasone and Loxapine inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depression from antipsychotic receptor blockade and H1 antagonism.
What to do
Observe the patient for sedation after loxapine administration as required by the program. No dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Loxapine inhaled?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Loxapine inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Inhaled loxapine causes sedation and can cause bronchospasm, and it is given under supervision. Azelastine may add to the drowsiness.
How serious is the interaction between Azelastine-fluticasone and Loxapine inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe the patient for sedation after loxapine administration as required by the program. No dose change is needed.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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