Drug interactions
Azelastine-fluticasone + Marijuana
Severity: Minor
Azelastine-fluticasone and Marijuana: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis causes drowsiness and impaired psychomotor performance, which may be intensified by azelastine. Nasal azelastine exposure is low, so the effect is usually mild.
What this interaction means in plain words
Azelastine-fluticasone and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depression through cannabinoid receptor activity and H1 antagonism.
What to do
Counsel the patient to avoid driving or operating machinery if drowsy. Reduce the cannabis dose if excess sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Marijuana?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabis causes drowsiness and impaired psychomotor performance, which may be intensified by azelastine. Nasal azelastine exposure is low, so the effect is usually mild.
How serious is the interaction between Azelastine-fluticasone and Marijuana?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid driving or operating machinery if drowsy. Reduce the cannabis dose if excess sedation occurs.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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