Drug interactions
Azelastine-fluticasone + Midazolam intranasal
Severity: Minor
Azelastine-fluticasone and Midazolam intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a CYP3A4 substrate, and fluticasone and azelastine are not clinically significant CYP3A4 inhibitors. Azelastine may add some sedation, though nasal exposure is low.
What this interaction means in plain words
Azelastine-fluticasone and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; any CYP3A4 inhibition is not clinically established.
What to do
Use the usual midazolam dose and monitor the level of sedation. Use caution with concurrent sedatives.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azelastine-fluticasone and Midazolam intranasal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Midazolam intranasal?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Midazolam is a CYP3A4 substrate, and fluticasone and azelastine are not clinically significant CYP3A4 inhibitors. Azelastine may add some sedation, though nasal exposure is low.
How serious is the interaction between Azelastine-fluticasone and Midazolam intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the usual midazolam dose and monitor the level of sedation. Use caution with concurrent sedatives.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
