Drug interactions
Azelastine-fluticasone + Opium tincture
Severity: Moderate
Azelastine-fluticasone and Opium tincture: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine nasal spray can cause drowsiness in some patients, and opium tincture is a potent opioid sedative. Taken together they may deepen sedation and impair alertness, and respiratory depression is possible with the opioid component.
What this interaction means in plain words
Azelastine-fluticasone and Opium tincture can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from the antihistamine and the opioid.
What to do
Counsel the patient to avoid driving and other hazardous tasks until the response is known. Monitor sedation and respiratory rate, and use the lowest effective opioid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Opium tincture?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Opium tincture can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azelastine nasal spray can cause drowsiness in some patients, and opium tincture is a potent opioid sedative. Taken together they may deepen sedation and impair alertness, and respiratory depression is possible with the opioid component.
How serious is the interaction between Azelastine-fluticasone and Opium tincture?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid driving and other hazardous tasks until the response is known. Monitor sedation and respiratory rate, and use the lowest effective opioid dose.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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