Drug interactions
Azelastine-fluticasone + Phenobarbital
Severity: Moderate
Azelastine-fluticasone and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is a long-acting barbiturate that causes sedation, and azelastine can add to drowsiness. Impaired alertness and psychomotor performance are more likely with the combination.
What this interaction means in plain words
Azelastine-fluticasone and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from antihistamine and barbiturate effects.
What to do
Monitor for excessive sedation and counsel against driving until the response is known. Reduce doses if drowsiness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Phenobarbital?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital is a long-acting barbiturate that causes sedation, and azelastine can add to drowsiness. Impaired alertness and psychomotor performance are more likely with the combination.
How serious is the interaction between Azelastine-fluticasone and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and counsel against driving until the response is known. Reduce doses if drowsiness is troublesome.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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