Drug interactions
Azelastine-fluticasone + Valerian
Severity: Minor
Azelastine-fluticasone and Valerian: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian is a herbal sedative that may increase the drowsiness caused by azelastine. Clinical evidence is limited and the effect is probably modest.
What this interaction means in plain words
Azelastine-fluticasone and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression, likely GABAergic.
What to do
Advise the patient to watch for added drowsiness and avoid driving if affected. Stop valerian if sedation is excessive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Valerian?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valerian is a herbal sedative that may increase the drowsiness caused by azelastine. Clinical evidence is limited and the effect is probably modest.
How serious is the interaction between Azelastine-fluticasone and Valerian?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to watch for added drowsiness and avoid driving if affected. Stop valerian if sedation is excessive.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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