Drug interactions
Azelastine-fluticasone + Yohimbine
Severity: Minor
Azelastine-fluticasone and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine is a sedating antihistamine, whereas yohimbine is an alpha-2 antagonist that tends to cause central stimulation and anxiety. Their effects on alertness may partly oppose each other, but the net result is unpredictable and no clinically meaningful interaction has been well documented.
What this interaction means in plain words
Azelastine-fluticasone and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing central effects (histamine H1 blockade versus alpha-2 adrenergic antagonism); the net effect is not firmly established.
What to do
No dose change is needed; counsel the patient that sedation may vary and review alertness before driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Yohimbine?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azelastine is a sedating antihistamine, whereas yohimbine is an alpha-2 antagonist that tends to cause central stimulation and anxiety. Their effects on alertness may partly oppose each other, but the net result is unpredictable and no clinically meaningful interaction has been well documented.
How serious is the interaction between Azelastine-fluticasone and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; counsel the patient that sedation may vary and review alertness before driving.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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