Drug interactions
Azficel-t + Indomethacin
Severity: Moderate
Azficel-t and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azficel-T involves biopsy and repeated intradermal injections, and NSAIDs can increase bruising and bleeding at these sites. The labeling advises against concomitant NSAID use around the procedures.
What this interaction means in plain words
Azficel-t and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-mediated platelet inhibition prolongs bleeding at biopsy and injection sites.
What to do
Hold indomethacin for the period around the biopsy and injection sessions as advised in the product labeling. Use an alternative analgesic such as paracetamol if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Azficel-t with Indomethacin?
MediHelp rates the interaction as moderate. Azficel-t and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azficel-T involves biopsy and repeated intradermal injections, and NSAIDs can increase bruising and bleeding at these sites. The labeling advises against concomitant NSAID use around the procedures.
How serious is the interaction between Azficel-t and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold indomethacin for the period around the biopsy and injection sessions as advised in the product labeling. Use an alternative analgesic such as paracetamol if needed.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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