Drug interactions
Azficel-t + Oxaprozin
Severity: Moderate
Azficel-t and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azficel-T is given by intradermal injection after a skin biopsy, and NSAIDs impair platelet function. Patients taking oxaprozin may therefore have more bruising or bleeding at biopsy and injection sites.
What this interaction means in plain words
Azficel-t and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reversible inhibition of platelet cyclooxygenase by oxaprozin reduces platelet aggregation and prolongs bleeding at procedure sites.
What to do
Hold oxaprozin before the biopsy and injection sessions as advised in the azficel-T labeling, and use alternative analgesia such as paracetamol. Inspect injection sites for bleeding and hematoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Azficel-t with Oxaprozin?
MediHelp rates the interaction as moderate. Azficel-t and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azficel-T is given by intradermal injection after a skin biopsy, and NSAIDs impair platelet function. Patients taking oxaprozin may therefore have more bruising or bleeding at biopsy and injection sites.
How serious is the interaction between Azficel-t and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold oxaprozin before the biopsy and injection sessions as advised in the azficel-T labeling, and use alternative analgesia such as paracetamol. Inspect injection sites for bleeding and hematoma.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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