Drug interactions
Azilsartan + Bretylium
Severity: Moderate
Azilsartan and Bretylium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lower blood pressure, and bretylium can cause orthostatic hypotension. Combined use may cause additive hypotension with dizziness or syncope.
What this interaction means in plain words
Azilsartan and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from angiotensin receptor blockade and adrenergic neuron blockade.
What to do
Monitor blood pressure, including standing readings, when starting or adjusting either drug. Reduce the azilsartan dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Azilsartan with Bretylium?
MediHelp rates the interaction as moderate. Azilsartan and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can lower blood pressure, and bretylium can cause orthostatic hypotension. Combined use may cause additive hypotension with dizziness or syncope.
How serious is the interaction between Azilsartan and Bretylium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, when starting or adjusting either drug. Reduce the azilsartan dose if symptomatic hypotension occurs.
What other medicines interact with Azilsartan?
MediHelp also lists interactions of Azilsartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Azilsartan page.
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