Drug interactions
Azilsartan + Insulin nph
Severity: Moderate
Azilsartan and Insulin nph: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may enhance insulin sensitivity, which can increase hypoglycemia risk in insulin-treated patients. The effect is generally mild but can be relevant early in therapy.
What this interaction means in plain words
Azilsartan and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable improved insulin sensitivity with ARBs adding to insulin's glucose-lowering effect; the mechanism is not firmly established.
What to do
Increase glucose monitoring when azilsartan is started or its dose changed, and reduce the insulin dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Azilsartan with Insulin nph?
MediHelp rates the interaction as moderate. Azilsartan and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers may enhance insulin sensitivity, which can increase hypoglycemia risk in insulin-treated patients. The effect is generally mild but can be relevant early in therapy.
How serious is the interaction between Azilsartan and Insulin nph?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase glucose monitoring when azilsartan is started or its dose changed, and reduce the insulin dose if hypoglycemia develops.
What other medicines interact with Azilsartan?
MediHelp also lists interactions of Azilsartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Azilsartan page.
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