Drug interactions
Azilsartan + Ketorolac
Severity: Moderate
Azilsartan and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac can blunt the blood pressure lowering effect of azilsartan. Together they also raise the risk of acute kidney injury, especially in elderly, dehydrated or volume-depleted patients.
What this interaction means in plain words
Azilsartan and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces afferent arteriolar dilation and sodium excretion, which counteracts the ARB and, combined with angiotensin II receptor blockade, impairs glomerular filtration.
What to do
Keep the ketorolac course as short as possible and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium, and avoid the combination in patients with existing renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Azilsartan with Ketorolac?
MediHelp rates the interaction as moderate. Azilsartan and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac can blunt the blood pressure lowering effect of azilsartan. Together they also raise the risk of acute kidney injury, especially in elderly, dehydrated or volume-depleted patients.
How serious is the interaction between Azilsartan and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the ketorolac course as short as possible and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium, and avoid the combination in patients with existing renal impairment.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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