Drug interactions
Azilsartan + Nitroglycerin rectal
Severity: Moderate
Azilsartan and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrates and angiotensin receptor blockers both lower blood pressure, so combined use can cause additive hypotension, dizziness or syncope. The effect is typically manageable but more pronounced in volume-depleted or older patients.
What this interaction means in plain words
Azilsartan and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and blood pressure lowering through different pharmacodynamic pathways.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug, and advise patients to change position slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Azilsartan with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Azilsartan and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrates and angiotensin receptor blockers both lower blood pressure, so combined use can cause additive hypotension, dizziness or syncope. The effect is typically manageable but more pronounced in volume-depleted or older patients.
How serious is the interaction between Azilsartan and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug, and advise patients to change position slowly.
What other medicines interact with Azilsartan?
MediHelp also lists interactions of Azilsartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Azilsartan page.
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