Drug interactions
Azilsartan + Olanzapine / samidorphan
Severity: Moderate
Azilsartan and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension, which may add to the blood pressure lowering of azilsartan. Patients may experience dizziness or falls, particularly at initiation.
What this interaction means in plain words
Azilsartan and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effect from olanzapine alpha-1 adrenergic blockade and angiotensin receptor blockade.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating either drug. Reduce the azilsartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Azilsartan with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Azilsartan and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension, which may add to the blood pressure lowering of azilsartan. Patients may experience dizziness or falls, particularly at initiation.
How serious is the interaction between Azilsartan and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating either drug. Reduce the azilsartan dose if hypotension occurs.
What other medicines interact with Azilsartan?
MediHelp also lists interactions of Azilsartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Azilsartan page.
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