Drug interactions
Azilsartan + Potassium citrate / citric acid
Severity: Moderate
Azilsartan and Potassium citrate / citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azilsartan reduces aldosterone-mediated potassium excretion, and potassium supplements add to the potassium load, so hyperkalemia can develop. The risk is highest with renal impairment, diabetes or other potassium-raising drugs.
What this interaction means in plain words
Azilsartan and Potassium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARB-induced aldosterone suppression reduces renal potassium excretion while exogenous potassium adds to the body load.
What to do
Check serum potassium and renal function at baseline and periodically, particularly in the first weeks. Reduce or stop the potassium product if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Azilsartan with Potassium citrate / citric acid?
MediHelp rates the interaction as moderate. Azilsartan and Potassium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azilsartan reduces aldosterone-mediated potassium excretion, and potassium supplements add to the potassium load, so hyperkalemia can develop. The risk is highest with renal impairment, diabetes or other potassium-raising drugs.
How serious is the interaction between Azilsartan and Potassium citrate / citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function at baseline and periodically, particularly in the first weeks. Reduce or stop the potassium product if potassium rises.
What other medicines interact with Azilsartan?
MediHelp also lists interactions of Azilsartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Azilsartan page.
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