Drug interactions
Azilsartan + Salsalate
Severity: Moderate
Azilsartan and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates such as salsalate may blunt the blood pressure lowering of angiotensin receptor blockers and add to the risk of renal function decline. Older, volume-depleted or renally impaired patients are most vulnerable.
What this interaction means in plain words
Azilsartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, counteracting ARB effects and stressing glomerular filtration.
What to do
Monitor blood pressure, serum creatinine and potassium when combining, and keep the patient well hydrated. Use the lowest effective salsalate dose or consider an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Azilsartan with Salsalate?
MediHelp rates the interaction as moderate. Azilsartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates such as salsalate may blunt the blood pressure lowering of angiotensin receptor blockers and add to the risk of renal function decline. Older, volume-depleted or renally impaired patients are most vulnerable.
How serious is the interaction between Azilsartan and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when combining, and keep the patient well hydrated. Use the lowest effective salsalate dose or consider an alternative analgesic.
What other medicines interact with Azilsartan?
MediHelp also lists interactions of Azilsartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Azilsartan page.
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