Drug interactions
Azilsartan + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Azilsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid loss and electrolyte shifts, and volume depletion in a patient on an angiotensin receptor blocker raises the risk of acute kidney injury and hypotension. Electrolyte disturbances may also contribute to arrhythmias.
What this interaction means in plain words
Azilsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Preparation-induced volume depletion and electrolyte shifts reduce renal perfusion, which is poorly tolerated with RAS blockade.
What to do
Ensure adequate hydration before and during bowel preparation, and consider withholding azilsartan on the day of the preparation. Check renal function and electrolytes in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Azilsartan with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Azilsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid loss and electrolyte shifts, and volume depletion in a patient on an angiotensin receptor blocker raises the risk of acute kidney injury and hypotension. Electrolyte disturbances may also contribute to arrhythmias.
How serious is the interaction between Azilsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration before and during bowel preparation, and consider withholding azilsartan on the day of the preparation. Check renal function and electrolytes in high-risk patients.
What other medicines interact with Azilsartan?
MediHelp also lists interactions of Azilsartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Azilsartan page.
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