Drug interactions
Azilsartan + Synthetic human angiotensin ii
Severity: Moderate
Azilsartan and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azilsartan blocks the AT1 receptor through which angiotensin II raises blood pressure, so the pressor response to infused angiotensin II may be reduced. This could make it harder to correct hypotension in patients receiving an ARB.
What this interaction means in plain words
Azilsartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive AT1 receptor antagonism by azilsartan opposes the vasoconstrictor action of angiotensin II.
What to do
Anticipate a possibly blunted response and titrate angiotensin II to blood pressure, with continuous hemodynamic monitoring. Higher doses or additional vasopressors may be needed in patients on an ARB.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Azilsartan with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Azilsartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azilsartan blocks the AT1 receptor through which angiotensin II raises blood pressure, so the pressor response to infused angiotensin II may be reduced. This could make it harder to correct hypotension in patients receiving an ARB.
How serious is the interaction between Azilsartan and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Anticipate a possibly blunted response and titrate angiotensin II to blood pressure, with continuous hemodynamic monitoring. Higher doses or additional vasopressors may be needed in patients on an ARB.
What other medicines interact with Azilsartan?
MediHelp also lists interactions of Azilsartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Azilsartan page.
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