Drug interactions
Azilsartan-chlorthalidone + Bendroflumethiazide
Severity: Moderate
Azilsartan-chlorthalidone and Bendroflumethiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone is already a thiazide-like diuretic, so adding bendroflumethiazide duplicates therapy. This increases the risk of hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hypotension without a clear added benefit.
What this interaction means in plain words
Azilsartan-chlorthalidone and Bendroflumethiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Therapeutic duplication with additive inhibition of the distal tubule sodium-chloride cotransporter, leading to electrolyte loss and volume depletion.
What to do
Avoid combining two thiazide-type diuretics; use one agent only. If both were used, monitor electrolytes and renal function and stop the duplicate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Bendroflumethiazide?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Bendroflumethiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone is already a thiazide-like diuretic, so adding bendroflumethiazide duplicates therapy. This increases the risk of hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hypotension without a clear added benefit.
How serious is the interaction between Azilsartan-chlorthalidone and Bendroflumethiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazide-type diuretics; use one agent only. If both were used, monitor electrolytes and renal function and stop the duplicate.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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