Drug interactions
Azilsartan-chlorthalidone + Budesonide
Severity: Minor
Azilsartan-chlorthalidone and Budesonide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can promote potassium loss, which adds to chlorthalidone-induced hypokalemia. The risk is greater with systemic exposure and is small with inhaled or locally acting budesonide.
What this interaction means in plain words
Azilsartan-chlorthalidone and Budesonide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; Budesonide belongs to Respiratory.
Why it happens
Additive renal potassium wasting from mineralocorticoid activity and thiazide-like diuresis.
What to do
Monitor serum potassium when budesonide is used systemically or at high dose and supplement potassium if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Budesonide
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Budesonide?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Budesonide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids can promote potassium loss, which adds to chlorthalidone-induced hypokalemia. The risk is greater with systemic exposure and is small with inhaled or locally acting budesonide.
How serious is the interaction between Azilsartan-chlorthalidone and Budesonide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when budesonide is used systemically or at high dose and supplement potassium if low.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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