Drug interactions
Azilsartan-chlorthalidone + Carvedilol
Severity: Minor
Azilsartan-chlorthalidone and Carvedilol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol adds antihypertensive effect to azilsartan-chlorthalidone, which is often intended, but it may cause excessive hypotension, dizziness or bradycardia. Carvedilol may also impair glucose tolerance and mask hypoglycemia, a concern with thiazide-like diuretics that raise glucose.
What this interaction means in plain words
Azilsartan-chlorthalidone and Carvedilol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; Carvedilol belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering through alpha/beta blockade, angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure and heart rate when combining or titrating. Adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Carvedilol
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Carvedilol?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Carvedilol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carvedilol adds antihypertensive effect to azilsartan-chlorthalidone, which is often intended, but it may cause excessive hypotension, dizziness or bradycardia. Carvedilol may also impair glucose tolerance and mask hypoglycemia, a concern with thiazide-like diuretics that raise glucose.
How serious is the interaction between Azilsartan-chlorthalidone and Carvedilol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when combining or titrating. Adjust doses if symptomatic hypotension occurs.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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