Drug interactions
Azilsartan-chlorthalidone + Cefamandole
Severity: Minor
Azilsartan-chlorthalidone and Cefamandole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are secreted by renal tubular anion transport, so cefamandole might modestly raise chlorthalidone exposure. Clinical relevance is believed to be small.
What this interaction means in plain words
Azilsartan-chlorthalidone and Cefamandole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for organic anion transporter-mediated tubular secretion.
What to do
No routine action is needed; monitor blood pressure and electrolytes as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azilsartan-chlorthalidone and Cefamandole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Cefamandole?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Cefamandole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are secreted by renal tubular anion transport, so cefamandole might modestly raise chlorthalidone exposure. Clinical relevance is believed to be small.
How serious is the interaction between Azilsartan-chlorthalidone and Cefamandole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor blood pressure and electrolytes as usual.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
