Drug interactions
Azilsartan-chlorthalidone + Celiprolol
Severity: Moderate
Azilsartan-chlorthalidone and Celiprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone has been reported to lower celiprolol absorption and exposure, which may weaken beta-blockade. Both agents lower blood pressure, so the combined effect is generally additive and useful, but the net result can vary.
What this interaction means in plain words
Azilsartan-chlorthalidone and Celiprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide diuretics reduce celiprolol gastrointestinal absorption by a mechanism that is not fully established, while the pharmacodynamic effects on blood pressure are additive.
What to do
Monitor blood pressure and heart rate after starting or changing either drug. Adjust the celiprolol dose if response is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Celiprolol?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Celiprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone has been reported to lower celiprolol absorption and exposure, which may weaken beta-blockade. Both agents lower blood pressure, so the combined effect is generally additive and useful, but the net result can vary.
How serious is the interaction between Azilsartan-chlorthalidone and Celiprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate after starting or changing either drug. Adjust the celiprolol dose if response is reduced.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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