Drug interactions
Azilsartan-chlorthalidone + Cephalexin
Severity: Minor
Azilsartan-chlorthalidone and Cephalexin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are cleared partly by renal tubular anion secretion, so cephalexin might modestly raise chlorthalidone exposure. Clinical relevance is believed to be small.
What this interaction means in plain words
Azilsartan-chlorthalidone and Cephalexin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for organic anion transporter-mediated tubular secretion.
What to do
No routine action is needed; monitor blood pressure and electrolytes as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Cephalexin?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Cephalexin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are cleared partly by renal tubular anion secretion, so cephalexin might modestly raise chlorthalidone exposure. Clinical relevance is believed to be small.
How serious is the interaction between Azilsartan-chlorthalidone and Cephalexin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor blood pressure and electrolytes as usual.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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