Drug interactions
Azilsartan-chlorthalidone + Dichlorphenamide
Severity: Moderate
Azilsartan-chlorthalidone and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, and chlorthalidone both increase urinary potassium loss, so hypokalemia may be more pronounced. Dichlorphenamide also causes metabolic acidosis, which can complicate electrolyte disturbances.
What this interaction means in plain words
Azilsartan-chlorthalidone and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive renal potassium wasting from carbonic anhydrase inhibition and thiazide-like diuresis.
What to do
Monitor serum potassium and bicarbonate at baseline and periodically. Replace potassium or adjust therapy if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Dichlorphenamide?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, and chlorthalidone both increase urinary potassium loss, so hypokalemia may be more pronounced. Dichlorphenamide also causes metabolic acidosis, which can complicate electrolyte disturbances.
How serious is the interaction between Azilsartan-chlorthalidone and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and periodically. Replace potassium or adjust therapy if levels fall.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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