Drug interactions
Azilsartan-chlorthalidone + Epinephrine
Severity: Moderate
Azilsartan-chlorthalidone and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine drives potassium into cells through beta-2 stimulation, which can cause transient hypokalemia, and this adds to chlorthalidone-induced potassium loss. The effect can raise arrhythmia risk, particularly in patients with cardiac disease.
What this interaction means in plain words
Azilsartan-chlorthalidone and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Epinephrine belongs to Endocrine.
Why it happens
Beta-2 mediated cellular potassium uptake combined with diuretic-induced renal potassium wasting.
What to do
Check serum potassium when epinephrine is used repeatedly or in high doses, and correct hypokalemia. Monitor ECG in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Epinephrine?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine drives potassium into cells through beta-2 stimulation, which can cause transient hypokalemia, and this adds to chlorthalidone-induced potassium loss. The effect can raise arrhythmia risk, particularly in patients with cardiac disease.
How serious is the interaction between Azilsartan-chlorthalidone and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium when epinephrine is used repeatedly or in high doses, and correct hypokalemia. Monitor ECG in high-risk patients.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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