Drug interactions
Azilsartan-chlorthalidone + Fenbufen
Severity: Moderate
Azilsartan-chlorthalidone and Fenbufen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone and the active acidic metabolite of fenbufen are both organic acids handled by renal tubular secretion. Competition may modestly raise fenbufen exposure. NSAIDs can also blunt the antihypertensive and diuretic effect of thiazide-type diuretics and angiotensin receptor blockers and can impair renal function.
What this interaction means in plain words
Azilsartan-chlorthalidone and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular organic anion secretion, plus NSAID-related prostaglandin inhibition that reduces diuretic and antihypertensive efficacy and renal perfusion.
What to do
Monitor blood pressure, renal function and serum potassium when fenbufen is used with this combination, especially in older or volume-depleted patients. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Fenbufen?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone and the active acidic metabolite of fenbufen are both organic acids handled by renal tubular secretion. Competition may modestly raise fenbufen exposure. NSAIDs can also blunt the antihypertensive and diuretic effect of thiazide-type diuretics and angiotensin receptor blockers and can impair renal function.
How serious is the interaction between Azilsartan-chlorthalidone and Fenbufen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and serum potassium when fenbufen is used with this combination, especially in older or volume-depleted patients. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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