Drug interactions
Azilsartan-chlorthalidone + Fentanyl transmucosal
Severity: Minor
Azilsartan-chlorthalidone and Fentanyl transmucosal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl may reduce diuretic effectiveness through antidiuretic hormone release and can cause urinary retention. It may also add to the hypotension seen with the antihypertensive combination.
What this interaction means in plain words
Azilsartan-chlorthalidone and Fentanyl transmucosal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced ADH release and urinary retention oppose diuresis, with additive hypotensive effects.
What to do
Monitor blood pressure, volume status and urinary output, especially in men with prostatic enlargement. Reassess diuretic dose if fluid retention occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Fentanyl transmucosal?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Fentanyl transmucosal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fentanyl may reduce diuretic effectiveness through antidiuretic hormone release and can cause urinary retention. It may also add to the hypotension seen with the antihypertensive combination.
How serious is the interaction between Azilsartan-chlorthalidone and Fentanyl transmucosal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status and urinary output, especially in men with prostatic enlargement. Reassess diuretic dose if fluid retention occurs.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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