Drug interactions
Azilsartan-chlorthalidone + Fo-ti
Severity: Minor
Azilsartan-chlorthalidone and Fo-ti: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fo-ti (Polygonum multiflorum) has laxative properties from anthraquinone content, which could contribute to potassium loss. Together with chlorthalidone, this could worsen hypokalemia, though the evidence is theoretical. Fo-ti has also been linked to hepatotoxicity.
What this interaction means in plain words
Azilsartan-chlorthalidone and Fo-ti have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive potassium loss from anthraquinone-related laxative effect and thiazide-type kaliuresis; this is a theoretical mechanism.
What to do
Monitor serum potassium if fo-ti is used regularly with chlorthalidone. Advise patients to avoid prolonged use of fo-ti because of liver toxicity concerns.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Fo-ti?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Fo-ti have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fo-ti (Polygonum multiflorum) has laxative properties from anthraquinone content, which could contribute to potassium loss. Together with chlorthalidone, this could worsen hypokalemia, though the evidence is theoretical. Fo-ti has also been linked to hepatotoxicity.
How serious is the interaction between Azilsartan-chlorthalidone and Fo-ti?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium if fo-ti is used regularly with chlorthalidone. Advise patients to avoid prolonged use of fo-ti because of liver toxicity concerns.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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