Drug interactions
Azilsartan-chlorthalidone + Formoterol
Severity: Moderate
Azilsartan-chlorthalidone and Formoterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol can lower serum potassium through beta-2 stimulation, and this is additive to potassium loss from chlorthalidone. Hypokalemia may increase the risk of arrhythmia, especially at high doses or during acute asthma or COPD exacerbations.
What this interaction means in plain words
Azilsartan-chlorthalidone and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Formoterol belongs to Respiratory.
Why it happens
Beta-2 agonist-induced cellular potassium uptake adds to diuretic-induced renal potassium loss.
What to do
Monitor serum potassium, especially with high-dose formoterol or acute exacerbations. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Formoterol?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Formoterol can lower serum potassium through beta-2 stimulation, and this is additive to potassium loss from chlorthalidone. Hypokalemia may increase the risk of arrhythmia, especially at high doses or during acute asthma or COPD exacerbations.
How serious is the interaction between Azilsartan-chlorthalidone and Formoterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially with high-dose formoterol or acute exacerbations. Replace potassium as needed.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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