Drug interactions
Azilsartan-chlorthalidone + Glibenclamide
Severity: Minor
Azilsartan-chlorthalidone and Glibenclamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone may raise blood glucose and reduce the effectiveness of glyburide. Patients may need closer glycemic monitoring after the diuretic is introduced.
What this interaction means in plain words
Azilsartan-chlorthalidone and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; Glibenclamide belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia and impaired insulin secretion and sensitivity oppose the hypoglycemic action of the sulfonylurea (pharmacodynamic antagonism).
What to do
Monitor blood glucose and HbA1c after starting chlorthalidone, and adjust the glyburide dose if control worsens. Correct hypokalemia if present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Glibenclamide?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorthalidone may raise blood glucose and reduce the effectiveness of glyburide. Patients may need closer glycemic monitoring after the diuretic is introduced.
How serious is the interaction between Azilsartan-chlorthalidone and Glibenclamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting chlorthalidone, and adjust the glyburide dose if control worsens. Correct hypokalemia if present.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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