Drug interactions
Azilsartan-chlorthalidone + Heparin
Severity: Moderate
Azilsartan-chlorthalidone and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin can suppress aldosterone secretion and cause hyperkalemia, and the risk is additive with an ARB. It is most relevant in renal impairment, diabetes or prolonged heparin therapy, while chlorthalidone may partially offset it.
What this interaction means in plain words
Azilsartan-chlorthalidone and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Heparin belongs to Cardiovascular.
Why it happens
Heparin inhibits adrenal aldosterone synthesis, adding to angiotensin receptor blockade and reducing renal potassium excretion.
What to do
Monitor serum potassium and renal function during heparin therapy lasting more than a few days. Treat hyperkalemia if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Heparin?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin can suppress aldosterone secretion and cause hyperkalemia, and the risk is additive with an ARB. It is most relevant in renal impairment, diabetes or prolonged heparin therapy, while chlorthalidone may partially offset it.
How serious is the interaction between Azilsartan-chlorthalidone and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function during heparin therapy lasting more than a few days. Treat hyperkalemia if it develops.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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