Drug interactions
Azilsartan-chlorthalidone + Hydrocortisone
Severity: Moderate
Azilsartan-chlorthalidone and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both chlorthalidone and corticosteroids promote potassium loss, so combined use can cause hypokalemia. Hydrocortisone has mineralocorticoid activity, and low potassium may predispose to arrhythmias and weakness.
What this interaction means in plain words
Azilsartan-chlorthalidone and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from thiazide-type diuresis and corticosteroid mineralocorticoid effect.
What to do
Monitor serum potassium and magnesium, particularly with prolonged or high-dose steroid therapy, and supplement potassium as needed. The azilsartan component may partly offset potassium loss.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Hydrocortisone
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- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Hydrocortisone?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both chlorthalidone and corticosteroids promote potassium loss, so combined use can cause hypokalemia. Hydrocortisone has mineralocorticoid activity, and low potassium may predispose to arrhythmias and weakness.
How serious is the interaction between Azilsartan-chlorthalidone and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly with prolonged or high-dose steroid therapy, and supplement potassium as needed. The azilsartan component may partly offset potassium loss.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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