Drug interactions
Azilsartan-chlorthalidone + Indacaterol inhaled
Severity: Moderate
Azilsartan-chlorthalidone and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-2 agonists can lower serum potassium and non-potassium-sparing diuretics such as chlorthalidone add to this. Hypokalemia may predispose to arrhythmias, particularly in patients with hypoxia or heart disease.
What this interaction means in plain words
Azilsartan-chlorthalidone and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 stimulation moves potassium into cells, adding to renal potassium loss from the thiazide-like diuretic.
What to do
Monitor serum potassium, especially at initiation and in patients with severe COPD or cardiac disease. Correct hypokalemia and consider potassium supplementation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azilsartan-chlorthalidone and Indacaterol inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-2 agonists can lower serum potassium and non-potassium-sparing diuretics such as chlorthalidone add to this. Hypokalemia may predispose to arrhythmias, particularly in patients with hypoxia or heart disease.
How serious is the interaction between Azilsartan-chlorthalidone and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially at initiation and in patients with severe COPD or cardiac disease. Correct hypokalemia and consider potassium supplementation.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
