Drug interactions
Azilsartan-chlorthalidone + Insulin degludec / insulin aspart
Severity: Moderate
Azilsartan-chlorthalidone and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone may raise blood glucose and reduce the effect of insulin, while ARBs can modestly increase insulin sensitivity and hypoglycemia risk. Glycemic control may therefore fluctuate when either drug is started or changed.
What this interaction means in plain words
Azilsartan-chlorthalidone and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-like diuretics impair glucose tolerance, possibly via hypokalemia, whereas ARBs may enhance insulin sensitivity.
What to do
Monitor blood glucose when starting, stopping or changing doses. Adjust the insulin dose as needed and keep potassium normal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone may raise blood glucose and reduce the effect of insulin, while ARBs can modestly increase insulin sensitivity and hypoglycemia risk. Glycemic control may therefore fluctuate when either drug is started or changed.
How serious is the interaction between Azilsartan-chlorthalidone and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, stopping or changing doses. Adjust the insulin dose as needed and keep potassium normal.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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