Drug interactions
Azilsartan-chlorthalidone + Insulin inhaled
Severity: Moderate
Azilsartan-chlorthalidone and Insulin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone can raise blood glucose and reduce the effectiveness of insulin, so higher insulin doses may be needed. Azilsartan may slightly improve insulin sensitivity, so the net effect on glucose is variable.
What this interaction means in plain words
Azilsartan-chlorthalidone and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-like diuretics impair glucose tolerance and insulin secretion, possibly partly via hypokalemia, while ARBs may improve insulin sensitivity.
What to do
Monitor blood glucose when starting or changing the diuretic and adjust the insulin dose as needed. Keep serum potassium normal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Insulin inhaled?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone can raise blood glucose and reduce the effectiveness of insulin, so higher insulin doses may be needed. Azilsartan may slightly improve insulin sensitivity, so the net effect on glucose is variable.
How serious is the interaction between Azilsartan-chlorthalidone and Insulin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing the diuretic and adjust the insulin dose as needed. Keep serum potassium normal.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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