Drug interactions
Azilsartan-chlorthalidone + Ketorolac intranasal
Severity: Moderate
Azilsartan-chlorthalidone and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is an NSAID and, even by the nasal route, can reduce renal prostaglandin synthesis. With an ARB and a diuretic this raises the risk of acute kidney injury, especially with volume depletion, and may blunt the blood pressure effect.
What this interaction means in plain words
Azilsartan-chlorthalidone and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and promotes sodium retention, compounding the hemodynamic effects of an ARB plus diuretic.
What to do
Limit ketorolac to the shortest course and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium, particularly in older or volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is an NSAID and, even by the nasal route, can reduce renal prostaglandin synthesis. With an ARB and a diuretic this raises the risk of acute kidney injury, especially with volume depletion, and may blunt the blood pressure effect.
How serious is the interaction between Azilsartan-chlorthalidone and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to the shortest course and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium, particularly in older or volume-depleted patients.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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