Drug interactions
Azilsartan-chlorthalidone + Ketorolac
Severity: Major
Azilsartan-chlorthalidone and Ketorolac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac can blunt the antihypertensive effect and substantially increases the risk of acute kidney injury when combined with an ARB and a diuretic, especially in volume-depleted or elderly patients.
What this interaction means in plain words
Azilsartan-chlorthalidone and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan-chlorthalidone belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces glomerular perfusion and causes sodium retention in the presence of angiotensin blockade and diuresis.
What to do
Avoid or limit ketorolac to a very short course, ensuring hydration. Monitor creatinine, potassium and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Ketorolac?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac can blunt the antihypertensive effect and substantially increases the risk of acute kidney injury when combined with an ARB and a diuretic, especially in volume-depleted or elderly patients.
How serious is the interaction between Azilsartan-chlorthalidone and Ketorolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or limit ketorolac to a very short course, ensuring hydration. Monitor creatinine, potassium and blood pressure.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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