Drug interactions
Azilsartan-chlorthalidone + Levalbuterol
Severity: Moderate
Azilsartan-chlorthalidone and Levalbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levalbuterol, a beta-2 agonist, drives potassium into cells and can lower serum potassium, particularly at higher doses. Chlorthalidone also causes potassium loss in the urine, so the two together can produce clinically relevant hypokalemia and raise the risk of arrhythmia in susceptible patients.
What this interaction means in plain words
Azilsartan-chlorthalidone and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 mediated intracellular potassium shift and thiazide-like diuretic renal potassium wasting.
What to do
Check serum potassium and magnesium in patients using frequent or high-dose levalbuterol, and replace potassium as needed. Pay particular attention in patients with heart disease or in those taking other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Levalbuterol?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levalbuterol, a beta-2 agonist, drives potassium into cells and can lower serum potassium, particularly at higher doses. Chlorthalidone also causes potassium loss in the urine, so the two together can produce clinically relevant hypokalemia and raise the risk of arrhythmia in susceptible patients.
How serious is the interaction between Azilsartan-chlorthalidone and Levalbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium in patients using frequent or high-dose levalbuterol, and replace potassium as needed. Pay particular attention in patients with heart disease or in those taking other QT-prolonging drugs.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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