Drug interactions
Azilsartan-chlorthalidone + Magnesium chloride
Severity: Minor
Azilsartan-chlorthalidone and Magnesium chloride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone increases urinary magnesium loss and can lead to hypomagnesemia with long-term use. Magnesium chloride supplementation may offset this loss and does not create a harmful interaction. In advanced renal impairment, supplemental magnesium can accumulate.
What this interaction means in plain words
Azilsartan-chlorthalidone and Magnesium chloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-type diuretics increase renal magnesium excretion, which lowers magnesium levels and may reduce the effect of supplements.
What to do
Monitor serum magnesium and adjust supplementation as needed, taking renal function into account.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Magnesium chloride?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Magnesium chloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorthalidone increases urinary magnesium loss and can lead to hypomagnesemia with long-term use. Magnesium chloride supplementation may offset this loss and does not create a harmful interaction. In advanced renal impairment, supplemental magnesium can accumulate.
How serious is the interaction between Azilsartan-chlorthalidone and Magnesium chloride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and adjust supplementation as needed, taking renal function into account.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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