Drug interactions
Azilsartan-chlorthalidone + Magnesium sulfate
Severity: Minor
Azilsartan-chlorthalidone and Magnesium sulfate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone increases renal magnesium wasting and may lower serum magnesium. Magnesium sulfate given parenterally or orally replaces magnesium, so the effect is mostly an offset of the supplement. Hypomagnesemia from thiazides can worsen arrhythmia risk.
What this interaction means in plain words
Azilsartan-chlorthalidone and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-type diuretics increase renal magnesium excretion, which lowers magnesium levels and may reduce the supplement's effect.
What to do
Monitor serum magnesium and potassium and adjust replacement; use caution with dosing in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azilsartan-chlorthalidone and Magnesium sulfate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Magnesium sulfate?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorthalidone increases renal magnesium wasting and may lower serum magnesium. Magnesium sulfate given parenterally or orally replaces magnesium, so the effect is mostly an offset of the supplement. Hypomagnesemia from thiazides can worsen arrhythmia risk.
How serious is the interaction between Azilsartan-chlorthalidone and Magnesium sulfate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and potassium and adjust replacement; use caution with dosing in renal impairment.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
