Drug interactions
Azilsartan-chlorthalidone + Meclofenamate
Severity: Major
Azilsartan-chlorthalidone and Meclofenamate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can blunt the blood pressure lowering of ARBs and diuretics through sodium and water retention. In volume-depleted or elderly patients, the combination of an NSAID, ARB, and diuretic can cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Azilsartan-chlorthalidone and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
NSAID inhibition of renal prostaglandins reduces afferent arteriolar dilation, which combined with ARB efferent dilation and diuretic volume depletion impairs glomerular filtration and counteracts antihypertensive effects.
What to do
Avoid regular NSAID use where possible; use the lowest dose for the shortest duration if required. Monitor blood pressure, serum creatinine, and potassium, and ensure adequate hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Meclofenamate?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs such as meclofenamate can blunt the blood pressure lowering of ARBs and diuretics through sodium and water retention. In volume-depleted or elderly patients, the combination of an NSAID, ARB, and diuretic can cause acute kidney injury and hyperkalemia.
How serious is the interaction between Azilsartan-chlorthalidone and Meclofenamate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible; use the lowest dose for the shortest duration if required. Monitor blood pressure, serum creatinine, and potassium, and ensure adequate hydration.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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