Drug interactions
Azilsartan-chlorthalidone + Nitroglycerin rectal
Severity: Moderate
Azilsartan-chlorthalidone and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin is a vasodilator that lowers blood pressure, and combining it with an ARB and a diuretic can produce additive hypotension. Patients may experience dizziness, syncope, or reduced organ perfusion.
What this interaction means in plain words
Azilsartan-chlorthalidone and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and blood pressure lowering from nitrate-mediated venodilation with angiotensin receptor blockade and diuretic volume reduction.
What to do
Monitor blood pressure, especially after the first doses and in volume-depleted patients. Advise slow position changes and reduce the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin is a vasodilator that lowers blood pressure, and combining it with an ARB and a diuretic can produce additive hypotension. Patients may experience dizziness, syncope, or reduced organ perfusion.
How serious is the interaction between Azilsartan-chlorthalidone and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially after the first doses and in volume-depleted patients. Advise slow position changes and reduce the antihypertensive dose if hypotension occurs.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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